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PG01

PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 increases ΔF508-CFTR Cl- currents upon addition of forskolin. F508-CFTR Cl-current upon addition of Forskolin, correcting the gating defect of CFTR mutants.

Product Specifications

CAS Number

853138-65-5

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

439.55

Molecular Formula

C28H29N3O2

Notes

Research use only, not for human use.

Receptor

CFTR

Available Sizes

Frequently Asked Questions

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