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Lometrexol

Lometrexol (LY 264618), an antipurine Antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and Apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor.

Product Specifications

CAS Number

106400-81-1

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

443.45

Molecular Formula

C21H25N5O6

Notes

Research use only, not for human use.

Receptor

DHFR

Available Sizes

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