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SB-657510

SB-657510 is a urotensin II (UII) receptor (UT) antagonist. The Ki values of UT for human, monkey, cat, rat and mouse were 61, 17, 30, 65 and 56 nM, respectively. SB-657510 plays an anti-inflammatory role by inhibiting UII-induced inflammatory mediators, such as adhesion molecules, in human vascular endothelial cells and upregulation of cytokines and tissue factors. SB 657510 has a therapeutic effect on diabetes-related atherosclerotic disease in diabetic mouse models.

Product Specifications

CAS Number

474960-44-6

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

505.81

Molecular Formula

C19H22BrClN2O5S

Notes

Research use only, not for human use.

Receptor

Neurotensin Receptor

Available Sizes

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