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CSRM617 hydrochloride

CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer .

Product Specifications

CAS Number

1353749-74-2

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

291.69

Molecular Formula

C10H14ClN3O5

Notes

Research use only, not for human use.

Receptor

Apoptosis | Androgen Receptor

Available Sizes

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