CSRM617 hydrochloride
CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor), with a Kd of 7.43 µM in SPR assays, directly binding to the OC2-HOX domain. CSRM617 hydrochloride induces apoptosis through the appearance of cleaved Caspase-3 and PARP and is well tolerated in the mouse model of prostate cancer .
Product Specifications
CAS Number
1353749-74-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
291.69
Molecular Formula
C10H14ClN3O5
Notes
Research use only, not for human use.
Receptor
Apoptosis | Androgen Receptor
Available Sizes
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