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Cot inhibitor-1

Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM) . Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer.

Product Specifications

CAS Number

915365-57-0

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

553.46

Molecular Formula

C27H27Cl2FN8

Notes

Research use only, not for human use.

Receptor

MAPK | TNF

Available Sizes

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