Cot inhibitor-1
Cot inhibitor-1 is a selective inhibitor of Cot protein kinase (also known as Tpl2 or MAP3K8) (IC50 at 28 nM) . Cot inhibitor-1 inhibited TNF-alpha production in human whole blood with IC50 of 5.7 nM. Cot is involved in a variety of cellular signaling pathways, particularly those involved in inflammation and immune responses. Cot inactivate-1 inhibits Cot activity and may have potential therapeutic effects on rheumatoid arthritis, inflammatory bowel disease and some types of cancer.
Product Specifications
CAS Number
915365-57-0
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
553.46
Molecular Formula
C27H27Cl2FN8
Notes
Research use only, not for human use.
Receptor
MAPK | TNF
Available Sizes
More Discoveries
Explore Other Products
Browse additional items from our catalog
![Rabbit Polyclonal SAP30L Antibody [Alexa Fluor 350]](https://cdn.genprice.uk/genprice/uk/genprice5.webp)
NB100-491AF350 0.1 mL
Rabbit Polyclonal SAP30L Antibody [Alexa Fluor 350]
Sign In for Pricing
View Details 
TL516501V 500 µL Each
Zfp395 Mouse shRNA Lentiviral Particle (Locus ID 380912)
Sign In for Pricing
View Details NBP1-78403AF350 0.1 mL
Rabbit Polyclonal 5-HT4 Antibody [Alexa Fluor 350]
Sign In for Pricing
View Details 
MBS6425027-01 0.1 mL
LTBP2 (Latent Transforming Growth Factor Beta Binding Protein 2, WMS3, GLC3D, LTBP3, MSPKA, MSTP031, C14orf141) (MaxLight 405)
Sign In for Pricing
View Details MBS6425027-02 5x 0.1 mL
LTBP2 (Latent Transforming Growth Factor Beta Binding Protein 2, WMS3, GLC3D, LTBP3, MSPKA, MSTP031, C14orf141) (MaxLight 405)
Sign In for Pricing
View Details