JGB1741
JGB1741 is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-mediated apoptosis. JGB1741 can be used in studies about breast cancer.
Product Specifications
CAS Number
1256375-38-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
440.56
Molecular Formula
C27H24N2O2S
Notes
Research use only, not for human use.
Receptor
Aurora B
Available Sizes
Curated Selection
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