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Tanzisertib

Tanzisertib (CC-930) is a potent inhibitor of JNK1/2/3 with IC50s of 61/7/6 nM, respectively, with potential antifibrotic activity.Tanzisertib (CC-930) inhibits the formation of phospho-cJun in human PBMC stimulated by phorbol-12-myristate-13-acetate and phytohemeagglutinin (IC50=1 μM) [1] and it blocks the JNK pathway that is activated by pro-fibrotic cytokines in systemic sclerosis.

Product Specifications

CAS Number

899805-25-5

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

448.44

Molecular Formula

C21H23F3N6O2

Notes

Research use only, not for human use.

Receptor

JNK3|JNK2|JNK1

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