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Pyr6

Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells) .Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca (2+) entry and currents as well as mast cell activation with similar potency.

Product Specifications

CAS Number

245747-08-4

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

418.27

Molecular Formula

C17H9F7N4O

Notes

Research use only, not for human use.

Receptor

TRPC3

Available Sizes

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