Pyr6
Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells) .Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.Pyr3 is selective inhibitor of TRPC3, inhibited Orai1- and TRPC3-mediated Ca (2+) entry and currents as well as mast cell activation with similar potency.
Product Specifications
CAS Number
245747-08-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
418.27
Molecular Formula
C17H9F7N4O
Notes
Research use only, not for human use.
Receptor
TRPC3
Available Sizes
Curated Selection
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