Epimagnolin A

Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion. A herbal compound fargesin obtained from M. fargesii, has exerted anti-inflammatory effects in human monocytic THP-1 cells in the previous study. it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA) -induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.