A-674563 2HCl (552325-73-2 (fb-2hcl) )
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC.A-674563 reduces phosphorylation of Akt downstream targets in cells and slows proliferation of tumor cells in vitro (EC50: 0.4 μM) [1]. A563 (0-10 μM) markedly decreases GSK3 and MDM2 phosphorylation in STS cells.
Product Specifications
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
431.36
Molecular Formula
C22H24Cl2N4O
Notes
Research use only, not for human use.
Receptor
Akt1|CDK2|PKA|ERK2|PKCδ
Available Sizes
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