PRX-07034

PRX-07034 is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents. PRX-07034 is both a potent (Ki = 4-8 nM) and highly selective 5-HT (6) receptor antagonist (≥100-fold selectivity for the 5-HT (6) receptor compared to 68 other GPCRs, ion channels, and transporters, except D (3) (Ki = 71 nM) and 5-HT (1B) (Ki = 260 nM) receptors.