BMS986260
BMS-986260 is a selective, and orally bioavailable TGFβR1 inhibitor (IC50 = 1.6 nM) . BMS-986260 demonstrated functional activity in multiple TGFβ-dependent cellular assays, excellent kinome selectivity, favorable pharmacokinetic properties, and curative in vivo efficacy in combination with anti-PD-1 antibody in murine colorectal cancer (CRC) models.
Product Specifications
CAS Number
2001559-19-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
382.07
Molecular Formula
C18H12ClFN6O
Notes
Research use only, not for human use.
Receptor
TGFβR1
Available Sizes
Curated Selection
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