ML-180
ML-180 is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) inverse agonist (IC50 of 3.7 µM) .ML-180 (0.5-5 µM; 24 hours) shows a significant inhibition of cyclin-D1 and cyclin-E1 expression in hepatic cells, but has little effect on repression in SK-OV-3 cells[2]. ML-180 (5 µM; 24 hours) leads to a rapid decrease of LRH-1 expression and efficiently represses endogenous LRH-1 signaling.
Product Specifications
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
388.89
Molecular Formula
C20H25ClN4O2
Notes
Research use only, not for human use.
Receptor
Orphan nuclear receptor NR5A2
CAS Number
863588-32-3
Available Sizes
Curated Selection
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