MYCi975
MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411, SK-N-B2 cells viability in an MYC-dependent manner (IC50s of 3.7, 3.9, 6.4 μM, respectively) .The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index.
Product Specifications
CAS Number
2289691-01-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
561.3
Molecular Formula
C25H16Cl2F6N2O2
Notes
Research use only, not for human use.
Receptor
MYC