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MYCi975

MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411, SK-N-B2 cells viability in an MYC-dependent manner (IC50s of 3.7, 3.9, 6.4 μM, respectively) .The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index.

Product Specifications

CAS Number

2289691-01-4

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

561.3

Molecular Formula

C25H16Cl2F6N2O2

Notes

Research use only, not for human use.

Receptor

MYC

Available Sizes

Frequently Asked Questions

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