MYCi975
MYCi975 is an orally active inhibitor of MYC.MYCi975 inhibits P493-6, MV411, SK-N-B2 cells viability in an MYC-dependent manner (IC50s of 3.7, 3.9, 6.4 μM, respectively) .The initial lead, MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy. However, 361 demonstrated a narrow therapeutic index.
Product Specifications
CAS Number
2289691-01-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
561.3
Molecular Formula
C25H16Cl2F6N2O2
Notes
Research use only, not for human use.
Receptor
MYC
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog