Pyr10
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1) /Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) (IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells) .
Product Specifications
CAS Number
1315323-00-2
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
449.37
Molecular Formula
C18H13F6N3O2S
Notes
Research use only, not for human use.
Receptor
TRPC3
Available Sizes
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