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Pyr10

Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor. Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1) /Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) (IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells) .

Product Specifications

CAS Number

1315323-00-2

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

449.37

Molecular Formula

C18H13F6N3O2S

Notes

Research use only, not for human use.

Receptor

TRPC3

Available Sizes

Curated Selection

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