Y-33075 dihydrochloride

Y-33075 dihydrochloride is a selective inhibitor of ROCK (IC50 of 3.6 nM) .Y-33075 (Y-39983) is a potent inhibitor of ROCK (IC50 of 3.6 nM) . Y-33075 also inhibits PKC and CaMKII more potently than Y-27632 (IC50s of Y-27632 and Y-33075 for PKC are 9.0 μM and 0.42 μM, respectively), whereas the IC50s of Y-27632 and Y-33075 for CaMKII are 26 μM and 0.81 μM, respectively.