CC-92480
CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.CC-92480-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. It exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. CC-92480 is effective in CC-4047, CC-5013, and CC-220-resistant cell lines.
Product Specifications
CAS Number
2259648-80-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
567.61
Molecular Formula
C32H30FN5O4
Notes
Research use only, not for human use.
Receptor
E1/E2/E3 Enzyme
Available Sizes
Curated Selection
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