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CC-92480

CC-92480 is a cereblon E3 ubiquitin ligase modulating drug (CELMoD) with potent antimyeloma activity.CC-92480-induced loss of Aiolos and Ikaros in cultures of PBMCs resulted in the activation of T cells and increased production of IL-2 and IFN-γ. It exerts single-agent induction of apoptosis and exhibits remarkable synergy with NSC 34521. CC-92480 is effective in CC-4047, CC-5013, and CC-220-resistant cell lines.

Product Specifications

CAS Number

2259648-80-9

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

567.61

Molecular Formula

C32H30FN5O4

Notes

Research use only, not for human use.

Receptor

E1/E2/E3 Enzyme

Available Sizes

Frequently Asked Questions

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