Basimglurant
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric (Kd of 1.1 nM) . In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM) .
Product Specifications
CAS Number
802906-73-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
325.77
Molecular Formula
C18H13ClFN3
Notes
Research use only, not for human use.
Receptor
MGlu5
Available Sizes
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