HLM006474

HLM006474 is a pan inhibitor of E2F. This inhibits E2F4 DNA-binding (IC50: 29.8 µM in A375 cells) .HLM006474 causes the viability of both SCLC and NSCLC lines (IC50 ranging from 15 to 75 µM) . HLM006474 displays little activities against E2F4 DNA-binding in A375 cells at 10 and 20 µM, apparently inhibits E2F4 DNA-binding at 40 µM, and increasingly suppresses the effect at 60 and 80 µM concentrations.