AV-412
AV-412 is an EGFR inhibitor (EGFR, EGFR T790M, EGFR L858R, EGFR L858R/T790M and ErbB2 with IC50s of 0.75, 0.79, 0.5, 2.3, 19 nM) .In cells, MP-412 inhibited autophosphorylation of EGFR and ErbB2 with IC (50) of 43 and 282 nM, respectively.
Product Specifications
CAS Number
451493-31-5
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
851.41
Molecular Formula
C41H44ClFN6O7S2
Notes
Research use only, not for human use.
Receptor
EGFR|EGFR (L858R) |EGFR (T790M) |EGFR (L858R/T790M) |ErbB2
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