KIRA6

KIRA6 is an effective inhibitor of IRE1α RNase kinase (IC50: 0.6 µM) . It can trigger an apoptotic response.KIRA6 (10-1000 nM, 72 hours) strongly compromises the viability of the KIT-dependent cell line HMC-1.1 at the low nM concentration, in a manner that coincided with KIT blockade.