Thalidomide-5-O-C9-NH2 (hydrochloride)

Thalidomide-5-O-C9-NH2 hydrochloride is the Thalidomide (HY-10984) -based cereblon ligand used in the recruitment of CRBN protein.Thalidomide-5-O-C9-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-5-o-c9-nh2-hydrochloride.html

Purity

99.59

Solubility

10 mM in DMSO

Smiles

O=C1C(C=CC(OCCCCCCCCCN)=C2)=C2C(N1C(CC3)C(NC3=O)=O)=O.Cl

Molecular Formula

C22H30ClN3O5

Molecular Weight

451.94

References & Citations

[1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512 (7512) :49-53. [Content Brief]