Imipramine (hydrochloride) (Standard)

Imipramine (hydrochloride) (Standard) is the analytical standard of Imipramine (hydrochloride) . This product is intended for research and analytical applications. Imipramine hydrochloride is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects[1][2][3][4][5].

Product Specifications

CAS Number

[113-52-0]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Reference Standards; Serotonin Transporter

Type

Reference Standards

Related Pathways

Apoptosis; Autophagy; Neuronal Signaling; Others

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/imipramine-hydrochloride-standard.html

Purity

99.52

Smiles

CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.[H]Cl

Molecular Formula

C19H25ClN2

Molecular Weight

316.87

Precautions

H302

References & Citations

[1]Alburquerque-González B, et al. New role of the antidepressant imipramine as a Fascin1 inhibitor in colorectal cancer cells. Exp Mol Med. 2020 Feb;52 (2) :281-292.|[2]Jeon SH, et al. The tricyclic antidepressant imipramine induces autophagic cell death in U-87MG glioma cells. Biochem Biophys Res Commun. 2011 Sep 23;413 (2) :311-7. |[3]Xia Z, et al. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13 (6) :338-47. |[4]Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.|[5]Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264 (4) :2195-8.