WNK463

WNK463 is an orally bioavailable pan-With-No-Lysine (K) (WNK) -kinase inhibitor with IC50s of 5 nM, 1 nM, 6 nM, and 9 nM for WNK1, WNK2, WNK3, and WNK4, respectively[1].

Product Specifications

CAS Number

[2012607-27-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

WNK Kinase

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/WNK463.html

Purity

99.75

Solubility

DMSO : ≥ 30 mg/mL

Smiles

FC(F)(F)C1=NN=C(O1)C2=CN=C(N3CCC(N4C=NC=C4C(NC(C)(C)C)=O)CC3)C=C2

Molecular Formula

C21H24F3N7O2

Molecular Weight

463.46

Precautions

H315, H319, H320

References & Citations

[1]Yamada K et al. Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat Chem Biol. 2016 Nov;12 (11) :896-898.|[2]Desjardins P, et al. Contribution of the WNK1 kinase to corneal wound healing using the tissue-engineered human cornea as an in vitro model. J Tissue Eng Regen Med. 2019 Sep;13 (9) :1595-1608.