WNK463
WNK463 is an orally bioavailable pan-With-No-Lysine (K) (WNK) -kinase inhibitor with IC50s of 5 nM, 1 nM, 6 nM, and 9 nM for WNK1, WNK2, WNK3, and WNK4, respectively[1].
Product Specifications
CAS Number
[2012607-27-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
WNK Kinase
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/WNK463.html
Purity
99.75
Solubility
DMSO : ≥ 30 mg/mL
Smiles
FC(F)(F)C1=NN=C(O1)C2=CN=C(N3CCC(N4C=NC=C4C(NC(C)(C)C)=O)CC3)C=C2
Molecular Formula
C21H24F3N7O2
Molecular Weight
463.46
Precautions
H315, H319, H320
References & Citations
[1]Yamada K et al. Small-molecule WNK inhibition regulates cardiovascular and renal function. Nat Chem Biol. 2016 Nov;12 (11) :896-898.|[2]Desjardins P, et al. Contribution of the WNK1 kinase to corneal wound healing using the tissue-engineered human cornea as an in vitro model. J Tissue Eng Regen Med. 2019 Sep;13 (9) :1595-1608.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
WNK1; WNK2; WNK3; WNK4
Available Sizes
Curated Selection
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