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P62-mediated mitophagy inducer

P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.

Product Specifications

CAS Number

1809031-84-2

Stability

≥ 2 years

Purity

>98% (HPLC)

Weight

392.156

Molecular Formula

C14H9IN4O2

Notes

Research use only, not for human use.

Receptor

Mitophagy

Available Sizes

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