Dehydroeffusol

Dehydroeffusol is a phenanthrene from medicinal herb Juncus effuses. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. It shows very low toxicity[1][2].

Product Specifications

CAS Number

[137319-34-7]

UNSPSC

12352005

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dehydroeffusol.html

Purity

99.55

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC=C2C3=C(C=C)C=C(O)C=C3C=CC2=C1C

Molecular Formula

C17H14O2

Molecular Weight

250.29

References & Citations

[1]Zhang B, et al. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. Biochem Pharmacol. 2016 Mar 15;104:8-18.|[2]Liu W, et al. Dehydroeffusol effectively inhibits human gastric cancer cell-mediated vasculogenic mimicry with low toxicity. Toxicol Appl Pharmacol. 2015 Sep 1;287 (2) :98-110.