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HBF-0259

HBF-0259 is a potent and selective inhibitor of hepatitis B virus (HBV) surface antigen (HBsAg) secretion, with an EC50 of 1.5 μM in HepG2.2.15 cells. HBF-0259 has no effect on HBV DNA synthesis[1][2].

Product Specifications

CAS Number

957011-15-3

UNSPSC

12352005

Target

HBV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hbf-0259.html

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(C2N=C3N(NN=N3)C(C4=C(F)C=CC=C4Cl)C2)C=C1

Molecular Formula

C16H12Cl2FN5

Molecular Weight

364.20

References & Citations

[1]Dougherty AM, et, al. A substituted tetrahydro-tetrazolo-pyrimidine is a specific and novel inhibitor of hepatitis B virus surface antigen secretion. Antimicrob Agents Chemother. 2007 Dec;51 (12) :4427-37.|[2]Yu W, et, al. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion. J Med Chem. 2011 Aug 25;54 (16) :5660-70.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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