L-Arginine-15N4 (hydrochloride)

L-Arginine-15N4 (hydrochloride) is the 15N-labeled L-Arginine hydrochloride. L-Arginine hydrochloride ((S) - (+) -Arginine hydrochloride) is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis[1].

Product Specifications

CAS Number

[204633-95-4]

Product Name Alternative

(S) - (+) -Arginine-15N4 (hydrochloride)

UNSPSC

12352211

Target

Endogenous Metabolite; Isotope-Labeled Compounds; NO Synthase

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/l-arginine-15n4-hydrochloride.html

Purity

99.94

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

[15NH]=C([15NH2])[15NH]CCC[C@H]([15NH2])C(O)=O.Cl

Molecular Formula

C6H15Cl 15N4O2

Molecular Weight

214.64

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56 (9) :439-45.|[3]Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002) . Crit Care Med. 2004 Jan;32 (1) :1-12.|[4]Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20 (4) :709-17.