3-Fluoro-evodiamine glucose
3-Fluoro-evodiamine glucose (Compound 8) is an evodiamine-glucose conjugate. 3-Fluoro-evodiamine glucose activates the expression of glucose transporter 1 (GLUT1), and inhibits topoisomerase I/II. 3-Fluoro-evodiamine glucose induces apoptosis and arrests the cell cycle at G2/M phase. 3-Fluoro-evodiamine glucose exhibits antitumor efficacy in vivo and in vitro, without significant toxicity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; GLUT; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-fluoro-evodiamine-glucose.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H]([C@H]([C@@H](O[C@@H]1CO)OC2=CC3=C(NC4=C3CCN5[C@]4([H])N(C6=C(C5=O)C=C(F)C=C6)C)C=C2)O)O
Molecular Formula
C25H26FN3O7
Molecular Weight
499.49
References & Citations
[1]Wu Z, et al., Design of Evodiamine-Glucose Conjugates with Improved In Vivo Antitumor Activity. J Med Chem. 2024 May 9;67 (9) :7373-7384.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GLUT1; Topo I; Topo II
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