FC-11
FC-11 is a PROTAC FAK degrader (DC90: 1 nM). FC-11 contains CRBN ligand Pomalidomide , linker and FAK ligand PF562271 (HY-10459).
Product Specifications
CAS Number
2271035-37-9
UNSPSC
12352005
Target
FAK; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fc-11.html
Purity
99.95
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
O=C(C1=CN(CCOCCOCCNC2=CC=CC(C(N3C4C(NC(CC4)=O)=O)=O)=C2C3=O)N=N1)NC5=CC=C(NC6=NC=C(C(F)(F)F)C(NCC7=CC=CN=C7N(S(=O)(C)=O)C)=N6)C=C5
Molecular Formula
C41H42F3N13O9S
Molecular Weight
949.91
References & Citations
[1]Gao H, et al. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11 (10) :1855-1862. Gao H, Wu Y, Sun Y, Yang Y, Zhou G, Rao Y. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11 (10) :1855-1862.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC740965-500 1x 500 µL
MUC1 / CA15-3 / EMA / CD227 (Epithelial Marker) (VU-11D1), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC740633-500 1x 500 µL
Von Willebrand Factor (3E2D10), CF740 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC041099-100 1x 100 µL
CD31 / PECAM-1 (C31.3 + C31.7 + C31.10), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472003-100 1x 100 µL
CD8b, Mouse (H35-17.2), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC881700-100 1x 100 µL
CD44v4 (Marker of Tumor Metastasis) (CD44v4/1700R), CF488A conjugate, 0.1mg/mL
Sign In for Pricing
View Details