Lerociclib (dihydrochloride)
Lerociclib dihydrochloride (G1T38 dihydrochloride) is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 1 nM and 2 nM for CDK4/CyclinD1 and CDK6/CyclinD3, respectively.
Product Specifications
CAS Number
[2097938-59-3]
Product Name Alternative
G1T38 (dihydrochloride)
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/G1T38_dihydrochloride.html
Purity
98.51
Solubility
H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1NCC2(N3C1=CC4=CN=C(NC5=NC=C(N6CCN(C(C)C)CC6)C=C5)N=C43)CCCCC2.Cl.Cl
Molecular Formula
C26H36Cl2N8O
Molecular Weight
547.52
References & Citations
[1]Bisi JE, et al. Preclinical development of G1T38: A novel, potent and selective inhibitor of cyclin dependent kinases 4/6 for use as an oral antineoplastic in patients with CDK4/6 sensitive tumors. Oncotarget. 2017 Jun 27;8 (26) :42343-42358.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
CDK1; CDK2; CDK4; CDK5; CDK6; CDK7; CDK9
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MPC1377K Each
Magic™ Membrane Protein Human TMTC2 (Transmembrane O-mannosyltransferase targeting cadherins 2) Full Length
Ask
View Details