PD158780

PD158780 is a potent EGFR family inhibitor with IC50s of 8 pM, 49, 52, 52 nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.

Product Specifications

CAS Number

[171179-06-9]

UNSPSC

12352005

Hazard Statement

H302

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PD158780.html

Purity

99.47

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

CNC1=CC2=C(NC3=CC(Br)=CC=C3)N=CN=C2C=N1

Molecular Formula

C14H12BrN5

Molecular Weight

330.18

Precautions

H302

References & Citations

[1]Fry DW, et al. Biochemical and antiproliferative properties of 4-[ar (alk) ylamino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor. Biochem Pharmacol. 1997 Oct 15;54 (8) :877-87.