PD158780
PD158780 is a potent EGFR family inhibitor with IC50s of 8 pM, 49, 52, 52 nM for EGFR, ErbB2, ErbB3, and ErbB4, respectively.
Product Specifications
CAS Number
171179-06-9
UNSPSC
12352005
Hazard Statement
H302
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PD158780.html
Purity
99.47
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
CNC1=CC2=C(NC3=CC(Br)=CC=C3)N=CN=C2C=N1
Molecular Formula
C14H12BrN5
Molecular Weight
330.18
Precautions
H302
References & Citations
[1]Fry DW, et al. Biochemical and antiproliferative properties of 4-[ar (alk) ylamino]pyridopyrimidines, a new chemical class of potent and specific epidermal growth factor receptor tyrosine kinase inhibitor. Biochem Pharmacol. 1997 Oct 15;54 (8) :877-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2; ErbB3/HER3; ErbB4/HER4
Available Sizes
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