MK2-IN-3

MK2-IN-3 is a potent and selective inhibitor of MAPKAP-K2 (MK-2), with an IC50 of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC50s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC50s>200 μM) . MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo[1].

Product Specifications

CAS Number

[724711-21-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MAPKAPK2 (MK2)

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mk2-in-3.html

Concentration

10mM

Purity

99.70

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C1C2=C(NC(C3=CC(C4=CC5=CC=CC=C5N=C4)=NC=C3)=C2)CCN1

Molecular Formula

C21H16N4O

Molecular Weight

340.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Anderson DR, et, al. Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) . J Med Chem. 2007 May 31;50 (11) :2647-54.