S-Adenosyl-L-methionine-13C

S-Adenosyl-L-methionine-13C (S-Adenosyl methionine-13C) is the 13C labeled S-Adenosyl-L-methionine (HY-B0617) . S-Adenosyl-L-methionine (S-Adenosyl methionine) is produced endogenously from methionine and ATP by action of the enzyme methionine adenosyltransferase and is an important orally active methyl group donor. S-Adenosyl-L-methionine is a dietary supplement with potent antidepressant effects, and has the potential for liver disease and osteoarthritis research[1][2][3].

Product Specifications

CAS Number

[74084-24-5]

Product Name Alternative

S-Adenosyl methionine-13C; Ademetionine-13C; AdoMet-13C

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-adenosyl-l-methionine-13c.html

Purity

99.93

Solubility

H2O : ≥ 50 mg/mL

Smiles

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](O)[C@@H](C[S+]([13CH3])CC[C@H](N)C([O-])=O)O3

Molecular Formula

C14 13CH22N6O5S

Molecular Weight

399.43

Precautions

H302, H315, H319, H335

References & Citations

[1]G M Bressa. S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies. Acta Neurol Scand Suppl. 1994;154:7-14.|[2]Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 265:6.|[3]Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct92 (4) :1515-42.