Vasicine (hydrochloride)

Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine hydrochloride activates PI3K/Akt signaling pathway, exhibits antioxidant, anti-inflammatory and antibacterial activities[1][2][3].

Product Specifications

CAS Number

[7174-27-8]

Product Name Alternative

Peganine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302

Target

Akt; Bacterial; PI3K

Type

Natural Products

Related Pathways

Anti-infection; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vasicine-hydrochloride.html

Concentration

10mM

Purity

98.88

Solubility

DMSO : ≥ 125 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

O[C@H]1CCN2C1=NC3=C(C=CC=C3)C2.[H]Cl

Molecular Formula

C11H13ClN2O

Molecular Weight

224.69

Precautions

H302

References & Citations

[1]Grange JM, et al. Activity of bromhexine and ambroxol, semi-synthetic derivatives of vasicine from the Indian shrub Adhatoda vasica, against Mycobacterium tuberculosis in vitro. J Ethnopharmacol. 1996 Jan;50 (1) :49-53.|[2]Jiang T, et al., Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway. Drug Des Devel Ther. 2019 Oct 31;13:3773-3784.|[3]Singh VK, et al., Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers. Phytomedicine. 2013 Oct 15;20 (13) :1180-5.