CIQ
Product Specifications
UNSPSC Description
CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit.
IC50 value: 2.7 μM (EC50, for NR2C) and 2.8 μM (EC50, NR2D)
Target: NMDA receptor
CIQ increases channel opening frequency of recombinant NR2Cor NR2D containing receptors by two-fold (EC50 = 2.7 and 2.8 μM, respectively), with no effect on NR2A or NR2B subtypes. CIQ does not alter the EC50 values for glutamate or glycine on channel opening. CIQ increases channel opening efficiency and enhances NMDA receptor responses. CIQ reduces associated behaviours in schizophrenia models and potentially enhances dopamine release in Parkinson's disease models.
Target Antigen
iGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/CIQ.html
Purity
99.75
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=CC=CC(Cl)=C1)N2C(COC3=CC=C(OC)C=C3)C4=C(C=C(OC)C(OC)=C4)CC2
Molecular Weight
467.94
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-18699/CIQ-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-18699/CIQ-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
486427-17-2
Available Sizes
Curated Selection
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