WL47
WL47, a high-affinity cavolin-1 (CAV1) ligand (Kd=23 nM), is a potent disrupter of CAV1 oligomers. WL47 shows selectivity for CAV1 over BSA, casein and HEWL. WL47 is 80% smaller in length than the original T20 parent sequence and can be used for the study of caveolin-1 function[1].
Product Specifications
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wl47.html
Solubility
10 mM in H2O
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCSC)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CO)C(N[C@@H](CS)C(N[C@@H](CS)C(N[C@@H](CO)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCSC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N
Molecular Formula
C80H130N24O17S4
Molecular Weight
1828.30
References & Citations
[1]Amanda J H Gilliam, et al. Affinity-Guided Design of Caveolin-1 Ligands for Deoligomerization. J Med Chem. 2016 Apr 28;59 (8) :4019-25.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
ACS Nano. 2024 Feb 27;18 (8) :6463-6476.|Adv Funct Mater. 2024 May 1.|J Cell Sci. 2025 Apr 7:jcs.263688.
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