GA 0113

GA 0113 is a potent and orally active angiotensin II (Ang II) AT1-receptor antagonist. GA 0113 inhibits the Ang II (HY-13948) -induced pressor response with ID50 of 0.032 mg/kg and dose-dependently increases plasma renin activity for 48 h[1].

Product Specifications

CAS Number

[200639-61-8]

UNSPSC

12352005

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ga-0113.html

Smiles

O=S(NC1=C(C2=NC3=C(C=C2)C=C(CN4C5=NC(C)=CC(C)=C5N=C4CC)C=C3)C=CC=C1)(C(F)(F)F)=O

Molecular Formula

C27H24F3N5O2S

Molecular Weight

539.57

References & Citations

[1]Ebisu H, et al. Pharmacologic profiles of GA0113, a novel quinoline derivative angiotensin II AT1-receptor antagonist. J Cardiovasc Pharmacol. 1999 Oct;34 (4) :526-32.