Setidegrasib
Product Specifications
UNSPSC Description
Setidegrasib (Example 8) is a PROTAC KRAS degrader. Setidegrasib is a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound, inducing the degradation of G12D-mutation KRAS protein. Setidegrasib is expected to be used in cancer research. (Blue: HY-168699; Black: linker (HY-168698); Pink: HY-168700)[1].
Target Antigen
PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein;MAPK/ERK Pathway;PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/setidegrasib.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C(C(C(C1CC1)=CC(C(N2[C@@](CN3)([H])C[C@@]3([H])C2)=N4)=C5N=C4OC6CCOCC6)=C5OCC7=CC=C(C(N=N8)=CN8[C@@H](C(C)C)C(N(C[C@@H]9O)[C@@H](C9)C(N[C@H](C%10=CC=C(C(SC=N%11)=C%11C)C=C%10)CO)=O)=O)C=C7)=C(C=NN%12)C%12=C%13)=C%13F
Molecular Weight
1117.30
References & Citations
[1]Yoshinari, et al. Preparation of quinazoline-linked (4R)-4-hydroxy-L-prolinamide compounds for inducing degradation of G12D-mutation KRAS protein: World Intellectual Property Organization, WO2022173032[P]. 2022-08-18.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-148273/Setidegrasib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-148273/Setidegrasib-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2821793-99-9
Available Sizes
Curated Selection
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