Setidegrasib
Setidegrasib (KRAS G12D inhibitor 17, ASP3082) is a PROTAC KRAS degrader (DC50: 37 nM). Setidegrasib induces the degradation of G12D-mutation KRAS protein. Setidegrasib suppresses p-ERK, p-AKT, p-S6 levels in AsPC-1 cells. Setidegrasib exhibits anti-tumor activity in various cancer xenograft models in mice. Setidegrasib can be used for the study of KRAS (G12D) -mutated solid tumors. (Blue: VHL ligase ligand ; Black: linker (HY-168698) ; Pink: G12D ligand (HY-168700) )[2].
Product Specifications
CAS Number
2821793-99-9
Product Name Alternative
ASP-3082; KRAS G12D inhibitor 17
UNSPSC
12352005
Target
Akt; ERK; PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PI3K/Akt/mTOR; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/setidegrasib.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
Molecular Formula
C60H65FN12O7S
Molecular Weight
1117.30
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras; von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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