PD159790

PD159790 is a selective endothelin-converting enzyme-1 (ECE-1) inhibitor, with an EC50 of 28.1 μM[1][2][3].

Product Specifications

CAS Number

[179598-53-9]

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pd159790.html

Smiles

FC(F)(F)C1=NC(NC2CN(CCC2)CC)=C3C=C(C=CC3=N1)I

Molecular Formula

C16H18F3IN4

Molecular Weight

450.24

References & Citations

[1]Janet Maguire, et al. Alternative pathway to endothelin-converting enzyme for the synthesis of endothelin in human blood vessels. J Cardiovasc Pharmacol. 2004 Nov:44 Suppl 1:S27-9.|[2]F D Russell, et al. Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells. Circ Res. 1999 Apr 30;84 (8) :891-6.|[3]K Ahn, et al. Novel selective quinazoline inhibitors of endothelin converting enzyme-1. Biochem Biophys Res Commun. 1998 Feb 4;243 (1) :184-90.