FB49

FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the Ki of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fb49.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C(C)C(N1CCOCC1)=O)C/2=O)SC2=C/C3=CC=CC(O)=C3O

Molecular Formula

C17H18N2O6S

Molecular Weight

378.40

References & Citations

[1]Budassi F, et al. Design, synthesis and biological evaluation of novel 2,4-thiazolidinedione derivatives able to target the human BAG3 protein [published online ahead of print, 2023 Sep 22]. Eur J Med Chem. 2023;261:115824.