ML291
ML291 is a UPR (unfolded protein response) -inducing sulfonamidebenzamide. ML291 overwhelms the adaptive capacity of the UPR and induces apoptosis in a variety of solid cancer models. ML291 can activate the PERK/eIF2a/CHOP (apoptotic) arm of the UPR and reduce leukemic cell burden[1].
Product Specifications
CAS Number
1523437-16-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Eukaryotic Initiation Factor (eIF) ; PERK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ml291.html
Purity
99.80
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(S(=O)(N3CCC(Cl)CC3)=O)C=C2
Molecular Formula
C16H16ClN3O6S
Molecular Weight
413.83
Precautions
H315, H319, H335
References & Citations
[1]Danielle Garshott, et al. The Novel Sulfonamidebenzamide ML291 Activates Apoptotic UPR Signaling in Pediatric Leukemia. Blood. 2016,128 (22) :3523.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EIF2
Available Sizes
Frequently Asked Questions
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